TheCrimsonHorror

WordPress is popular, Free software that can be used to quickly and easily build websites. It has great community support and a tonne of plugins that can extend it's capabilities. 

The problem is that it gets fucking hacked all the time, and abused to send billions of spam around the world.
Don't be an idiot and let yours get abused.

Securing wp-includes

A second layer of protection can be added where scripts are generally not intended to be accessed by any user. One way to do that is to block those scripts using mod_rewrite in the .htaccess file. Note: to ensure the code below is not overwritten by WordPress, place it outside the # BEGIN WordPress and # END WordPress tags in the .htaccess file. WordPress can overwrite anything between these tags.

# Block the include-only files.
<IfModule mod_rewrite.c>
RewriteEngine On
RewriteBase /
RewriteRule ^wp-admin/includes/ - [F,L]
RewriteRule !^wp-includes/ - [S=3]
RewriteRule ^wp-includes/[^/]+\.php$ - [F,L]
RewriteRule ^wp-includes/js/tinymce/langs/.+\.php - [F,L]
RewriteRule ^wp-includes/theme-compat/ - [F,L]
</IfModule>

# BEGIN WordPress

Note that this won't work well on Multisite, as RewriteRule ^wp-includes/[^/]+\.php$ - [F,L] would prevent the ms-files.php file from generating images. Omitting that line will allow the code to work, but offers less security.

Securing wp-config.php

You can move the wp-config.php file to the directory above your WordPress install. This means for a site installed in the root of your webspace, you can store wp-config.php outside the web-root folder.

Note that wp-config.php can be stored ONE directory level above the WordPress (where wp-includes resides) installation. Also, make sure that only you (and the web server) can read this file (it generally means a 400 or 440 permission).

If you use a server with .htaccess, you can put this in that file (at the very top) to deny access to anyone surfing for it:

<files wp-config.php>
order allow,deny
deny from all
</files>

Securing uploads

If file uploads are enabled, people can upload, and execute any arbitrary code, and use this to gain access to unintended areas of your site, or generate spam.
Creating a .htaccess file in the uploads folder with the following will prevent that.

<Files *.php>
deny from all
</Files>

Disable File Editing

The WordPress Dashboard by default allows administrators to edit PHP files, such as plugin and theme files. This is often the first tool an attacker will use if able to login, since it allows code execution. WordPress has a constant to disable editing from Dashboard. Placing this line in wp-config.php is equivalent to removing the 'edit_themes', 'edit_plugins' and 'edit_files' capabilities of all users:

define('DISALLOW_FILE_EDIT', true);

This will not prevent an attacker from uploading malicious files to your site, but might stop some attacks.

These are a few good places to start in securing your WP install. Of course keeping all updates applied to WordPress Core and any Plugins and Themes is very important as well.